Affiliation: OHSU Neurology & Biomedical Engineering
Funding Period: 2006 - 2012
Funding Source: NIA, Alzheimer's Disease Cooperative Study
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Abstract
Clinical trials for dementia prevention are currently being conducted worldwide. The end-points for efficacy in these trials rely on detecting small cognitive changes. Consequently, years of follow-up observation and large sample sizes are needed to detect these changes, and thus current trial methodology is not optimal. ORCATECH investigators (J. Kaye and T. Hayes) are leading this study with NIA Alzheimer’s Disease Cooperative Study investigators (M. Sano, PI) to develop new home based methods for improving the sensitivity of change detected as well as the efficiency of the trials themselves. The ADCS Home-Based Assessment study has randomized 600 seniors across 27 sites nationwide to compare automated delivery of questionnaires and neuropsychological tests using three methods: (1) An ORCATECH-designed home-based study kiosk using automated speech recognition and a MedTracker device to measure both medication adherence as well as an instrumented activity of daily living, (2) interactive voice recognition phone assessments and, (3) mailed paper questionnaires with live phone interview evaluations. The kiosk-MedTracker arm of the project is managed remotely using custom project management software.